Attentional set-shifting deficits correlate with the severity of freezing of gait in Parkinson's disease.
نویسندگان
چکیده
Freezing of gait (FOG) is a poorly understood symptom of Parkinson’s disease (PD) during which a patient suffers an abrupt cessation of walking [1]. Whilst little consensus exists regarding the mechanisms underlying FOG [2], there is considerable evidence that additional cognitive demand whilst walking represents a significant trigger in the pathophysiology of FOG [2]. In addition, the severity of self-reported FOG has been correlated with a selective deficit in attentional set-shifting [3]. Taken together, these findings suggest a degree of commonality between corticostriatal networks serving attention and the pathophysiology of FOG. However, no study has directly linked clinical measures of FOG severity during walking with diminished executive function, in particular the ability to rapidly switch between tasks. In this study we hypothesized that impaired behavioral performance on cognitive testing should correlate with objective measures of actual freezing events whilst walking.
منابع مشابه
Specific Attentional Disorders and Freezing of Gait in Parkinson's Disease.
BACKGROUND Due to its high prevalence in dual-task paradigms, freezing of gait in Parkinson's disease is thought to be associated with dysexecutive syndrome and attentional disorders. However, the role of specific attentional disorders in patients with freezing of gait is still unclear. OBJECTIVE Here, we sought to specifically determine which basic attentional modalities are impaired in pati...
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ورودعنوان ژورنال:
- Parkinsonism & related disorders
دوره 19 3 شماره
صفحات -
تاریخ انتشار 2013